The research team Molecular and Cellular Mechanisms of Pathogenic Infectious Agents (hereafter named MOCA, previously called I2T) in UM 134 PIMIT has been recreated in January 2020. MOCA team includes altogether a professor and associated-professors from La Reunion University, a senior researcher from INSERM, post-doc fellows, Master and PhD students, and a technician. The permanent staff has expertise in the fields of virology, cellular biology, immunology, chemistry and biochemistry. The current research programmes are mostly dedicated to medically-important arthropod-borne viruses (arboviruses) in the Indian ocean. The recent emergence of Zika virus in different regions of the world and the current epidemic of dengue virus in the Indian ocean including in La Reunion island are two remarkable examples of arbovirus propensity to spread in new areas causing major outbreaks. MOCA projects aim to analyze consequences of the host-pathogen interactions (with a particular emphasis on antiviral innate immunity and host metabolism disorders), to reveal important mechanisms involved in viral pathogenicity. MOCA team also seeks to apply knowledge acquired through basic research i) to develop biological tools for virus detection and diagnosis of pathogen-related disease, ii) to implement innovative therapies for viral infection prevention or treatment, as exemplified with the screening of antiviral compounds extracted from tropical medicinal plants, and iii) to design vaccine candidates, mostly live-attenuated viral strains using reverse genetic methods. The well-established collaborations with internationally-recognized research teams as well as biotechnology SME give an outstanding benefit to our current as well as future projects. Funding agency: POE FEDER 2014-20 du Conseil Général de La Région Réunion, EU-H2020, Research Federation BioST (Univ. La Réunion).
Head :DESPRES Philippe |
Permanent Staff
DESPRES Philippe | University Professor, Reunion University |
EL KALAMOUNI Chaker | Associate Professor, Reunion University |
GADEA Gilles | Associate Researcher, INSERM |
HOARAU Jean-Jacques | Associate Professor, HDR, Reunion University |
KREJBICH-TROTOT Pascale | Associate Professor, HDR, Reunion University |
ROCHE Marjolaine | Associate Professor, Reunion University |
ROQUEBERT Bénédicte | Associate Professor, Reunion University, PH CHU de La Réunion |
VIRANAICKEN Wildriss | Associate Professor, HDR, Reunion University |
Non permanents staff | |
DECOTTER Jason | Master 2, Université de La Réunion |
HADDAD Juliano | Post Doctorant, Université de La Réunion, FEDER |
OGIRE Eva | Doctorante, Université de La Réunion, Région Réunion |
RESTAN Alawiya | Master 2, Université de La Réunion |
TURPIN Jonathan | Doctorant, Université de La Réunion, MRT |
VANWALSCAPPEL Bénédicte | Post Doctorante, Université de La Réunion, FEDER |
Previous Members | |
2015 - 2020 | |
ALI MCOLO Zainabou | Master 2, (Université de La Réunion) |
BABET Valérie | Master 2, Université de La Réunion |
BEDOUI Yosra | Doctorante, Université de La Réunion, Région Réunion |
BOS Sandra | Doctorante, Université de La Réunion |
CLAIN Elodie | Doctorante, Université de La Réunion |
DOBRAVALSYTE Diana | Doctorante (Kaunas University, Lituania) |
FRUMENCE Etienne | Post Doctorant, Université de La Réunion, Région Réunion |
KADEL Sabina | Master 2 (Université de Toulouse) |
RAFFRAY Loïc | Doctorante, Université de La Réunion |
RALAMBONDRAINY Miora | Doctorante, Université de La Réunion |
RAMIN Stéphane | Master 1 (université de La Réunion) |
SORRES Jonathan | ATER, Université de La Réunion |
TUZIL Jan | Master 2 (Université de Montpellier) |
2019
- Clain E, Haddad, Koishi AC, Sinigaglia L, Rachidi W, Desprès P, Duarte dos Santos, CN, Guiraud P, Jouvenet N, El Kalamouni, C (2019). The polyphenol-rich extreact form Psiloxylon mauritianum, an endemic medicinal plant from Reunion island, inhibits the early stages of dengue and Zika virus infection. Int.J.Mol.Sci, 20, 1860 ; doi : 10.3390/ijms20081860
- El-Kalamouni C, Frumence E, Bos S, Turpin J, Nativel B, Harrabi W, Wilkinson DA, Meilhac O, Gadea G, Desprès P, Krejbich-Trodot P, Viranaicken W. (2018). Subversion of the Heme Oxygenase-1 antiviral activity by Zika virus. Viruses 11, 2 ; doi :10.3390/v11010002
- Haddad J. Koishi AC, Gaudry A, Duarte dos Satos CN, Viranicken W, Desprès P, El Kalamouni C (2019). Doratoxylon apetalum, an indigenous medicinal plant from Mascaren islands, is a potent inhibitor of Zika and dengue virus infection in human cells. Int.J.Mol.Sci, 20, 2382 ; doi : 10.3390/ijms20102382
- Li G, Bos S, Tsetsarkin K, Pletnev A, Desprès P, Gadea G, Zhao RY (2019). The roles of prM-E protein in historical and epidemic ZIka virus-mediated infection and neurocytotoxicity. Viruses, 11, 157 ; doi : 10.3390/v11020157
- Pascalis H, Turpin J, Roche M, Krejbich P, Gadea G, atyam Ngten C, Desprès P, Mavingui P. (2019). The epidemic of dengue virus type-2 Cosmopolitan genotype on Reunion island relates ot its active circulation in southweasgern indian ocean neighboring islands. Helyon, e01455
- Vanwalscappel B, Gadea G, Desprès P. A viperin mutant bearing the K358R substitution lost its anti-Zika virus activity. Int.J.Mol.Sci 20, 1574; doi : 10.3390/ijms20071574
2018
- Aubry M, Teissier A, Huart M, Merczron S, Vanhmwegen J, Mapotoeke M, Mariteragi-Helle T, Roche C, Berry AL, Teururai S, Sicard S, Paulous S, Desprès P, Manuguerra JC, Mallet HP, Imrie A, Musso D, Deparis X, Cao-Lormeau VM. (2018). Seroprevalence of dengue and Chikungunya viruses in French Polynesia, 2014-2015. Emerg Infect Dis., 24 : 558-61
- Bedoui, Y., Neal, J.W., Gasque, P. (2018). The neuro-immune-regulators (NIREGs) promote tissue résilience ; a vital component of the host’s defence strategy against neuroinflammation. J. Neuroimmune Pharmacol. In press. https://doi.org/10.1007/s11481-9793-6.
- Bedoui Y, Giry C, Jaffar-Bandjee MC, Selambarom J, Guiraud P, Gasque P. 2018. Immunomodulatory drug methotrexate used to treat patients with chronic inflammatory rheumatisms post-chikungunya does not impair the synovial antiviral and bone repair responses. PLoS neglected tropical diseases 12: e0006634;
- Bos S, Gadea G, Desprès P. (2018). Dengue : a growing threat requiring vaccine development for disease prevention. Pathog. Glob. Health. 112 : 294-305.
- Bos S, Viranaicken W, Turpin J, El-Kalamouni C, Krejbich-Trotot P, Desprès P, Gadea G. (2018). The structural proteins of epidemic and historical strains of Zika virus differ in the ability to initiate viral infection in human host cells. Virology, 516 : 265-73
- Clain E, Sinigaglia L, Koishi AC, Gorgette O, Gadea G, Viranaicken W, Krejbich-Trotot P, Mavingui P, Desprès P, Nunes Duarte Dos Santos C, Guiraud P, Jouvenet N, El-Kalamouni C. (2018). Extract from Aphloa theiformis : edible indigenous plant from Reunion island imparis Zika virus attachment to the host cell surface. Sci. Rep. 8: 10856
- Gaudry A, Bos S, Viranaicken W, Roche M, Krejbich-Trotot P, Gadea G, Desprès P, El-Kalamouni C. (2018). The Flavonoid isoquercitrin precludes initiation of Zika virus infection in human cells. Int.J.Mol.Sci 19, 1093; doi : 10.39390/ijms 19041093
- Griffiths MR, Botto M, Morgan BP, Neal JW, Gasque P. 2018. CD93 regulates central nervous system inflammation in two mouse models of autoimmune encephalomyelitis. Immunology 155: 346-55
- Lee I, Bos S, Li G, Gadea G., Desprès P, Zhao RY. (2018). Probing molecular insights into Zika virus interactions. Viruses 10, 233 ; doi: 10.3390/v10050233
- Raffray L, Giry C, Vandroux D, Fayeulle S, Moiton M-P, Gerber A, et al. The monocytosis during human leptospirosis is associated with modest immune cell activation states. Med Microbiol Immunol. 2018; doi:10.1007/s00430-018-0575-9
- Ralambondrainy M, Belarbi E, Viranaicken W, Baranauskienė R, Venskutonis PR, Desprès P, Roques P, El Kalamouni C, Sélambarom J. (2018). In vitro comparison of three common essential oils mosquito repellents as inhibitors of the Ross River virus. PloS One 13 :e0196757
2017
- Arsic N, Ho-Pun-Cheung A, Crapez E, Assenat E, Jarlier M, Anguille C, Colard M, Pezet M, Roux P, Gadea G (2017). The p53 isoform delta133p53ß regulates cancer cell apoptosis in a RhoB-dependent manner. PLoS One 12:e0175607
- Aubry M, Teissier A, Huart M, Merceron S, Vanhomwegen J, Roche C, Vial AL, Teururai S, Sicard S, Paulous S, Desprès P, Manuguerra JC, Mallet HP, Musso D, Deparis X, Cao-Lormeau VM (2017). Ross River virus seroprevalence, French Polynesia, 2014-15. Emerg Infect Dis. 23 :1751-3
- Aubry M, Teissier A, Huart M, Merceron S, Vanhomwegen J, Roche C, Vial AL, Teururai S, Sicard S, Paulous S, Desprès P, Manuguerra JC, Mallet HP, Musso D, Deparis X, Cao-Lormeau VM. (2017). Zika seroprevalence, French Polynesia, 2014-15. Emerging Infect. Dis. 23 :669-72
- Beaujois R, Ottoni E, Zhang X, Gagnon C, HSine S, Mollet S, Viranaicken W, DesGroseillers L. (2017). The M-phase specific hyperphosphorylation of Staufen2 involved the cyclin-dependent kinase CDK1. BMC Cell Biol. 18:25
- De Wispelaere M, Desprès P, Choumet V. (2017). European Aedes albopictus and Culex pipiens are competent vectors for Japanese encephalitis virus. PLoS Negl.Trop.Dis.:e0005294.
- Gasque P, Jaffae-Bandjee MC (2017). Blunting CHIKV infection by keeping T cells in check. Sci Transl Med 9 , pii :eeam 6567. https:// doi: 10.1126/scitranslmed.aam6567.
- Gérardin P, Cao-Lormeau VM, Musso D, Desprès P, Besnard M. (2017). Zika rash and increased risk of congenital brain adnormalities. Lancet 389 :151-152
- Goujon C, Gougeon ML, Tondeur L, Poirier B, Seffer V, Desprès P, Consigny PH, Vray M (2017). CHRONOVAC VOYAGEUR : A study of the immune response to yellow fever vaccine among infants previously immunized against measles. Vaccine 35 : 6166-71
- Lau C, Aubry M, Musso D, Teissier A, Paulous S, Desprès P, De Lamballerie X, Pastorino B, Cao-Lormeau M, Weinstein P. (2017). New evidence for endemic circulation of Ross River Virus in the Pacific Islands and potential for emergence. Int. J. Infect.Dis. 57 :73-76
- Nativel B, Couret D, Giraud P, Meilhac O, d'Hellencourt CL, Viranaicken W, Da Silva CR. (2017). Porphyromonas gingivalis lipopolysaccharides act exclusively through TLR4 with a resilience between mouse and human. Sci. Rep. 7 : 15789
- Raffray L, Giry C, Thirapathi Y, Reboux AH, Jaffar-Bandjee MC, Gasque P (2017). Increased levels of soluble forms of E-selection and ICAM-1 adhesion molecules during human leptospirosis. PloS One 12 :e0180474. https:// doi: 10.1371/journal.pone.0180474
- Tamba M, Caminiti A, Prosperi A, Desprès P, Lelli D, Galletti G, Moreno A, Paternoster G, Santi A, Licata E, Lecollinet S, Gelmini L, Rugna G, Procopio A, Lavazza A. (2017). Accuracy estimation of an indirect ELISA for the detection of West Nile virus antibodies in wild birds using a latent class model. J. Virol.Methods 248 : 202-06
- Vanhomwegen J, Beck C, Desprès P, Figuerola A, Garcia R, Lopez-Roig M, Manuguerra JC, Serra-Cobo (2017). Circulation of zoonotic arbovirus in equine populations of Mallorca Island (Spain). Vector Borne Zoonotic Dis. DOI : 10.1089/vbz.2016.2042
- Viranaicken W, Nativel B, Harrabi W, Krejbich-Trotot P, Bos S, El-Kalamouni C, Roche M, Gadea G, Desprès P (2017). ClearColi BL21(DE3)-based expression of Zika virus antigens illustrates a rapid method of antibody production against emerging pathogens. Biochimie 142 :179-82
- Viranaicken W, Ndebo A, Bos S, Souque P, Gadea G, El-Kalamouni C, Krejbich-Trotot P, Charneau P, Desprès P, Roche M. (2017). Recombinant Zika NS1 protein secreted from Vero cells is efficient for inducing production of immune serum against NS1 dimer. Int.J.Mol.Sci 19, 38 : doi :10.3390/imjs19010038
2016
- Alsaleh K, Khou C, Frenkiel MP, Lecollinet S, Vàzquez A, de Arellano ER, Desprès P, Pardigon N. (2016). The E glycoprotein plays an essential role in the high pathogenicity of European-Mediterranean IS98 strain of West Nile virus. Virology 492:53-65
- Breard E, Garnier A, Desprès P, Blaise Boisseau S, Comtet L, Viarouge C, Bakkali-Kassimi L, Pourquier P, Hudelet P, Vitour D, Rossi S, Belbis G, Sailleau C, Zientara S. (2016). Development of a Double-Antigen Microsphere Immunoassay for Simultaneous Group and Serotype Detection of Bluetongue Virus Antibodies. Transbound Emerg Dis. doi: 10.1111/tbed.12578
- Cao-Lormeau VM, Blake A, Mons S, Lastère S, Roche C, Vanhomwegen J, Dub T, Baudouin L, Teissier A, Larre P, Vial AL, Decam C, Choumet V, Halstead SK, Willison HJ, Musset L, Manuguerra JC, Desprès P, Fournier E, Mallet HP, Musso D, Fontanet A, Neil J, Ghawché F. (2016). Guillain-Barré Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study. Lancet. 387:1531-9
- Fernandez-Garcia MD, Meertens L, Chazal M, Hafirassou ML, Dejarnac O, Zamborlini A, Desprès P, Sauvonnet N, Arenzana-Seisdedos F, Jouvenet N, Amara A. (2016). Vaccine and Wild-Type Strains of Yellow Fever Virus Engage Distinct Entry Mechanisms and Differentially Stimulate Antiviral Immune Responses. MBio. 7:e01956-15
- Frumence E, Roche M, Krejbich-Trotot P, El-Kalamouni C, Nativel B, Rondeau P, Missé D, Gadea G, Viranaicken W, Desprès P (2016). The South Pacific epidemic strain of Zika virus replicates efficiently in human epithelial A549 cells leading to IFN-β production and apoptosis induction. Virology 493:217-26
- Gadea G, Bos S, Krejbich-Trotot P, Clain E, Viranaicken W, El-Kalamouni C, Mavingui P, Desprès P (2016). A robust method for the rapid generation of recombinant Zika virus expressing the GFP reporter gene. Virology 497:157-62
- Gasque P, Jaffar-Bandjee MC, Reyes MM, Viasus D (2016). Chikungunya pathogenesis : from the clinics to the bench. J. Infect. Dis. 214 (suppl. 5) : S446-448. https:// DOI:10.1093/infdis/jiw362
- Hamel R, Liégeois F, Wichit S, Pompon J, Diop F, Talignani L, Thomas F, Desprès P, Yssel H, Missé D. (2016). Zika virus: epidemiology, clinical features and host-virus interactions.Microbes Infect 18:441-9.
- Krejbich-Trotot P, Belarbi E, Ralambondrainy M, El-Kalamouni C, Viranaicken W, Roques P, Desprès P, Gadea G. (2016). The growth of arthralgic Ross River virus is restricted in human monocytic cells. Virus Res. 225:64-68
- Nativel B, Figuester A, Andries J, Planesse C, Couprie J, Gasque P, Viranaicken W, Iwema T. (2016). Soluble expression of disulfide-bonded C-lectin like domain of human CD93 in the cytoplasm of Escherichia col. J. Immunol. Methods 439 : 67-73
- Nemmiche, S., Guiraud, P. (2016). Cadmium-induced oxidase damages in the human BJAB cells correlate with changes in intracellular trace elements levels and zinc transporters expression. Toxicol In Vitro. 37:169-177. doi: 10.1016/j.tiv.2016.09.014.
- Raffray L, Giry C, Vandroux D, Kuli B, Randrianjohany A, Pequin AM, Renou F, Jaffar-Bandjee MC, Gasque P. (2016). Major neutrophilia observed in acute phase of human leptospirosis is not assocaited witn increased expression of granulocytes cell activation markers. PLoS One 11 : e0165716. https:// doi: 10.1371/journal.pone.0165716.
- Sanchez-David RY, Combredet C, Sismeiro O, Dillies MA, Jagla B, Coppée JY, Mura M, Guerbois Galla M, Desprès P, Tangy F, Komarova AV. (2016). Comparative analysis of viral RNA signatures on different RIG-I-like receptors. Elife 5:e11275
- Zhang X, Trépanier V, Beaujois R, Viranaicken W, Drobetsky E, DesGroseilleirs L (2016). The M-phase specific hyperphosphorylation of Staufen2 involved the cyclin-dependent kinase CDK1. Nucleic Acid Res. 44: 3695-712
2015
- Arsic N, Gadea G, Lagerquist EV, Busson M, Chauzak N, Brock C, Hollande F, Gire V, Pannequin J, Roux P (2015). The p53 isoform D133p53ß promotes cancer cell potential. Stem cell reports 14 : 531-40
- Aubry M, Finke J, Teissier A, Roche C, Broult J, Paulous S, Desprès P, Cao-Lormeau VM, Musso D. (2015).Fench Polynesia seroprevalence of arboviruses among blood donors in French Polynesia, 2011-2013. Int J Infect Dis. 41:11-2
- Aubry M, Finke J, Teissier A, Roche C, Broult J, Paulous S, Desprès P, Cao-Lormeau VM, Musso D. Silent Circulation of Ross River Virus in French Polynesia. Int J Infect Dis. 2015 37:19-24
- Beck C, Desprès P, Paulous S, Vanhomwegen J, Lowenski S, Nowotny N, Durand B, Garnier A, Blaise-Boisseau S, Guitton E, Yamanaka T, Zientara S, Lecollinet S. (2015). A High-Performance Multiplex Immunoassay for Serodiagnosis of Flavivirus-Associated Neurological Diseases in Horses. Biomed Res Int. doi: 10.1155/2015/678084
- Bruni D, Chazal M, Sinigaglia L, Chauveau L, Schwartz O, Desprès P, Jouvenet N. (2015). Viral entry route determines how human plasmacytoid dendritic cells produce type I interferons. Sci Signal. 2015 8:ra25. doi: 10.1126/scisignal.aaa1552
- Choumet V, Desprès P. (2015). Dengue and other flavivirus infections. Rev Sci Tech. 34 : 473-8, 467-72.
- De Wispelaere M, Frenkiel MP, Desprès P (2015). A Japanese encephalitis virus genotype 5 molecular clone is highly neuropathogenic in a mouse model: impact of the structural protein region on virulence. J Virol. 89:5862-75
- De Wispelaere M, Khou C, Frenkiel MP, Desprès P, Pardigon N. (2015). A Single Amino Acid Substitution in the M Protein Attenuates Japanese Encephalitis Virus in Mammalian Hosts. J Virol. 90 : 2676-89
- De Wispelaere M, Ricklin M, Souque P, Frenkiel MP, Paulous S, Garcìa-Nicolàs O, Summerfield A, Charneau P, Desprès P (2015). A Lentiviral Vector Expressing Japanese Encephalitis Virus-like Particles Elicits Broad Neutralizing Antibody Response in Pigs. PLoS Negl Trop Dis. 9 :e0004081
- Ekchariyawat P, Hamel R, Bernard E, Wichit S, Surasombatpattana P, Talignani L, Thomas F, Choumet V, Yssel H, Desprès P, Briant L, Missé D. (2015). Inflammasome signaling pathways exert antiviral effect against Chikungunya virus in human dermal fibroblasts. Infect Genet Evol. 32:401-8
- Gasque P, Jaffar-Bandjee MC (2015). The immunology and inflammatory responses of human melanocytes in infectious diseases. J. Infect. 71 :413-21. https:// doi: 10.1016/j.jinf.2015.06.006
- Gupta N, de Wispelaere M, Lecerf M, Kalia M, Scheel T, Vrati S, Berek C, Kaveri SV, Desprès P, Lacroix-Desmazes S, Dimitrov JD. (2015). Neutralization of Japanese Encephalitis Virus by heme-induced broadly reactive human monoclonal antibody. Sci Rep. 5:16248. doi: 10.1038/srep16248
- Hamel R, Dejarnac O, Wichit S, Ekchariyawat P, Neyret A, Luplertlop N, Perera-Lecoin M, Surasombatpattana P, Talignani L, Thomas F, Cao-Lormeau VM, Choumet V, Briant L, Desprès P, Amara A, Yssel H, Missé D. (2015). Biology of Zika Virus Infection in Human Skin Cells. J Virol. 89:8880-96
- Nedjadi T, El-Kafrawy S, Sohrab SS, Desprès P, Damanhouri G, Azhar E. (2015). Tackling dengue fever: Current status and challenges. Virol J. 12:212.
- Raffray L, Giry C, Thirapathi Y, Binois F, Moiton MP, Lagrange-Xelot M, Ferrandiz D, Jaffar-Bandjee MC, Gasque P. (2015). High leptospiremia is associated with gamma-delta T cell counts. Microbes Infect. 17 : 451-5. https:// doi: 10.1016/j.micinf.2015.04.001.
- Ramsauer K, Schwameis M, Firbas C, Müllner M, Putnak RJ, Thomas SJ, Desprès P, Tauber E, Jilma B, Tangy F. (2015). Immunogenicity, safety, and tolerability of a recombinant measles-virus-based chikungunya vaccine: a randomised, double-blind, placebo-controlled, active-comparator, first-in-man trial. Lancet Infect Dis. 15:519-27
- Rouvinski A, Guardado-Calvo P, Barba-Spaeth G, Duquerroy S, Vaney MC, Kikuti CM, Navarro Sanchez ME, Dejnirattisai W, Wongwiwat W, Haouz A, Girard-Blanc C, Petres S, Shepard WE, Desprès P, Arenzana-Seisdedos F, Dussart P, Mongkolsapaya J, Screaton GR, Rey FA. (2015). Recognition determinants of broadly neutralizing human antibodies against dengue viruses. Nature 520:109-13
- Simon-Loriere E, Lin RJ, Kalayanarooj SM, Chuansumrit A, Casademont I, Lin SY, Yu HP, Lert-Itthiporn W, Chaiyaratana W, Tangthawornchaikul N, Tangnararatchakit K, Vasanawathana S, Chang BL, Suriyaphol P, Yoksan S, Malasit P, Desprès P, Paul R, Lin YL, Sakuntabhai A. (2015). High anti-dengue virus activity of the OAS family is associated with increased severity of dengue. J. Infect.Dis. 212 : 2011-20
- Vera J, Lartigue L, Vigneron S, Gadea G, Gire V, Del Rio M, Soubeyran I, Chibon F, Lorca T, Castro A (2015). Greatwall promotes cell transformation by hyperactivating AKT in human malignancies. eLife pii :e10115