RAFFRAY Loïc

Research field:

-Host/pathogen interactions

-innate immunity in infectious process

Education

In the research field:

2017- 2018

Research fellow in Institute of Infection and Immunity at Cardiff University

Advisor: Pr Matthias Eberl, study of innate-like lymphocytes during sepsis

Grant from Marie-Curie European fellowship (1 year)

2013 - 2017

-PhD training at the University of La Réunion: Saint-Denis, Réunion Island.

Supervision of Pr Philippe Gasque, in the Mixt Unit of Research UMR PIMIT ‘Processus Infectieux en Milieu Insulaire Tropical’ INSERM 1187.

Work on immunopathology of leptospirosis.

PhD Viva in May 2017

2010

Master degree in Health and Biology, specialty Immunology and Microbiology at the Victor-Segalen Bordeaux 2 University, Bordeaux, France.

Internship in the laboratory of Pr Jean-François Moreau (Mixt Unit of Research 5164, University of Bordeaux)

Advisor: Dr J. Déchanet-Merville on the topic of Gamma-delta T cells in CMV infection in transplant recipients.

‘Fondation pour la Recherche Médicale’ grant

In the medical field: Victor-Segalen Bordeaux 2 University: Bordeaux, France.

2011

MD, Doctorate in Medicine, specialty of Internal Medicine and Complementary formation of Clinical Immunology

2013

Degree of pedagogy in Health and Higher Education.

Work experience

2011-2013

-Senior Registrar at the Bordeaux University Hospital and medical assistant in the internal medicine ward of Pr Longy-Boursier, St André Hospital at the Bordeaux Hospitals, France.

Since 2013

-Practioner in the internal medicine ward of Dr Yvin at the Hospital of St Denis in Réunion Island

Synthetic view of main publications in referenced journals with an impact factor >2:

Publications:

2019

- Lejri-El Euchi H, Chirpaz E, Foucher A, Sultan-Bichat N, Randrianjohany A, Poubeau P, Gamon E, Roussin C, Osdoit S, Raffray L. Vaccination against influenza and pneumococcal infections in patients with autoimmune disorders under biological therapy: coverage and attitudes in patients and physicians. Eur J Intern Med. 2019 Aug 21. pii: S0953-6205(19)30295-X. doi: 10.1016/j.ejim.2019.08.010.

-Vandroux D, Chanareille P, Delmas B, Gaüzère BA, Allou N, Raffray L, Jaffar-Bandjee MC, Martinet O, Ferdynus C, Jabot J. Acute respiratory distress syndrome in leptospirosis. J Crit Care. 2019 Jun;51:165-169. doi: 10.1016/j.jcrc.2019.02.018.

2018

-Raffray L, Giry C, Vandroux D, Fayeulle S, Moiton MP, Gerber A, Jaffar-Bandjee MC, Gasque P. The monocytosis during human leptospirosis is associated with modest immune cell activation states. Med Microbiol Immunol. 2018 Dec 12. doi: 10.1007/s00430-018-0575-9.

- Raffray L, Guillevin L. Treatment of eosinophilic granulomatosis with polyangiitis: a review. Drugs. 2018 May 15. Doi: 10.1007/s40265-018-0920-8.

-Delmas B, Jabot J, Chanareille P, Ferdynus C, Allyn J, Allou N, Raffray L, Gaüzere BA, Martinet O, Vandroux D. Leptospirosis in ICU: A Retrospective Study of 134 Consecutive Admissions. Crit Care Med. 2018 Jan;46(1):93-99. doi: 10.1097/CCM.0000000000002825.

-Gaüzère L, Gerber A, Renou F, Ferrandiz D, Bagny K, Osdoit S, Yvin JL, Raffray L. Caractéristiques du lupus érythémateux systémique à la Réunion : étude rétrospective en population adulte au CHU de Saint-Denis. Rev Med Interne. 2018 Jul 21. Doi :10.1016/j.revmed.2018.07.004.

2017

-Raffray L, Giry C, Thirapathi Y, Reboux AH, Jaffar-Bandjee MC, Gasque P. Increased levels of soluble forms of E-selectin and ICAM-1 adhesion molecules during human leptospirosis. PLoS One. 2017;12(7):e0180474. doi.org/10.1371/journal.pone.0180474.

-Lartigau-Roussin C, Paclet MH, Audin H, Toussaint B, Henni T, Raffray L. Macro-ASAT et myélome : une association fortuite? Rev Med Interne 2017 Mar;38(3):210-213.

-Raffray L, Renou F, Bourdier-de-Beauregard M, Lartigau-Roussin C, Mohamed S. Une maladie au traitement hautement compulsif. Rev Med Interne. 2017 Jan;38(1):65-68.  –Printemps de la médecine interne

- Audemard-Verger A, Terrier B, Dechartres A, Chanal J, Amoura Z, Le Gouellec N, Cacoub P, Jourde-Chiche N, Urbanski G, Augusto JF, Moulis G, Raffray L at al. Characteristics and Management of IgA Vasculitis (Henoch-Schönlein) in Adults: Data From 260 Patients Included in a French Multicenter Retrospective Survey. Arthritis Rheumatol. 2017 Sep;69(9):1862-1870. doi: 10.1002/art.40178.

2016

-Raffray L, Giry C, Vandroux D, Kuli B, Randrianjohany A, Pequin AM, Renou F, Jaffar-Bandjee MC, Gasque P. Major Neutrophilia Observed in Acute Phase of Human Leptospirosis Is Not Associated with Increased Expression of Granulocyte Cell Activation Markers. PLoS One. 2016 Nov 1;11(11):e0165716. doi:10.1371/journal.pone.0165716.

-Mekinian A, Grignano E, Braun T, Decaux O, Liozon E, Costedoat-Chalumeau N, Kahn JE, Hamidou M, Park S, Puéchal X, Toussirot E, Falgarone G, Launay D, Morel N, Trouiller S, Mathian A, Gombert B, Schoindre Y, Lioger B, De Wazieres B, Amoura Z, Buchdaul AL, Georgin-Lavialle S, Dion J, Madaule S, Raffray L et al. Systemic inflammatory and autoimmune manifestations associated with myelodysplastic syndromes and chronic myelomonocytic leukaemia: a French multicentre retrospective study. Rheumatology (Oxford) 2016 Feb;55(2):291-300.

-Bonnefond S, CatrouxM, MelenotteC, Karkowski L, Rolland L, Trouillier S, Raffray L. Clinical features of actinomycosis: a retrospective, multicenter study of 28 cases of miscellaneous presentations. Medicine (Baltimore), 2016 Jun;95(24):e3923. doi: 10.1097/MD.0000000000003923.

2015

-Raffray L, Rivière P, Bonnet H, Duffau P, Longy-Boursier M. Hépatite granulomateuse révélant une infection disséminée à Mycobacterium bovis après BCGthérapie intravésicale. Rev Med Interne 2015;36(9):626-30.

- Raffray L, Douchet I, Augusto JF, Youssef J, Contin-Bordes C, Richez C, Duffau P, Truchetet ME, Moreau JF, Cazanave C, Leroux L, Mourrissoux G, Camou F, Clouzeau B, Jeannin P, Delneste Y, Gabinski C, Guisset O, Lazaro E, Blanco P. Septic Shock Sera Containing Circulating Histones Induce Dendritic Cell-Regulated Necrosis in Fatal Septic Shock Patients. Crit Care Med 2015 Apr;43(4):e107-16.

-Raffray L, Giry C, Thirapathi Y, Binois F, Moiton MP, Lagrange-Xelot M, Ferrandiz D, Jaffar-Bandjee MC, Gasque P. High leptospiremia is associated with low gamma-delta T cell counts. Microbes Infect. 2015;17(6):451-5.

-Jacquemin C, Schmitt N, Contin-Bordes C, Liu Y, Narayanan P, Seneschal J, Maurouard T, Dougall D, Davizon ES, Dumortier H, Douchet I, Raffray L et al. OX40 Ligand contributes to human lupus pathogenesis by promoting T follicular helper response. Immunity 2015;42(6):1159-70.

2014

-Raffray L, Malvy D. Accidental intestinal myiasis caused by Eristalis tenax in France. Travel Med Infect Dis. 2014;12(1):109-10.

- Raffray L, Bertolotti A, Duffau P, Longueville E, Mercié P, Longy-Boursier M. Une exophtalmie. Presse Med. 2013;42(12):1674-7.

- Mekinian A, Braun T, Decaux O, Falgarone G, Toussirot E, Raffray L, et al. Inflammatory arthritis in patients with myelodysplastic syndromes: a multicenter retrospective study and literature review of 68 cases. Medicine (Baltimore) 2014;93(1):1-10.

- Raffray L, Receveur MC, Beguet M, Lauroua P, Pistone T, Malvy D. Severe delayed autoimmune haemolytic anaemia following artesunate administration in severe malaria: a case report. Malar J 2014;13:398.

2013 and previous years

-Renou F, Raffray L, Gerber A, Moiton MP, Ferrandiz D, Yvin JL. Localisation hépatique de la maladie des griffes du chat chez un immunocompétent. Med Mal Infect 2010 Mar;40(3):172-174.

-Raffray L, Couzi L, Viallard JF, Pellegrin JL, Augis V, Vernant JP, Merville P. Mycophenolate mofetil: a possible cause of hemophagocytic syndrome following renal transplantation? Am J Transplant 2010 Oct;10(10):2378-2379. (LR)

-Aouizerate J, Matignon M, Kamar N, Thervet E, Randoux C, Moulin B, Raffray L, Buchler M, Villar E, Mahevas M, Desvaux D, Dahan K, Diet C, Audard V, Lang P, Grimbert P. Renal transplantation in patients with sarcoidosis: a French multicenter study. Clin J Am Soc Nephrol 2010 Nov;5(11):2101-2108.

-Renou F, Wartel G, Raffray L, Kuli B, Fayeulle S, Yvin J. Arthrite réactionnelle dans les suites d’une infection urinaire à Escherichia coli. Rev Med Interne 2011 Jan;32(1):e4-5.

-Liozon E, Roussin C, Puéchal X, Garou A, Valadier P, Périnet I, Raffray L, Théry Y, De Lagarde B. Behçet's disease in East African patients may not be unusual and is an HLA-B51 negative condition: A case series from Mayotte (Comoros). Joint Bone Spine 2011;78(2):166-170.

-Raffray L, Diéval C, Viallard JF. Douleurs osseuses chroniques : métaplasie myéloïde. Presse Med 2013;42(1):117-9. (IC)

-Petitpierre F, Alberti N, Raffray L, Durieux M, Veron A, Perez J-T, et al. Embolie pulmonaire aiguë révélatrice d’un syndrome d’Ivemark chez un adulte. Journal de Radiologie Diagnostique et Interventionnelle 2013;94(3):333-5.

-Alberti N, Frulio N, Bertolotti A, Petitpierre F, Veron A, Perez JT, Raffray L, et al. La maladie d’Erdheim-Chester : un diagnostic rare à l’imagerie évocatrice. Journal de Radiologie Diagnostique et Interventionnelle 2013;94(4):457-9.

-Raffray L, Le Bail B, Malvy D. Hepatic visceral larva migrans presenting as a pseudotumor. Clin Gastroenterol Hepatol. 2013;11(6):e42. (LR)

 -Raffray L, Bertolotti A, Duffau P, Longueville E, Mercié P, Longy-Boursier M. Une exophtalmie. Presse Med. 2013;42(12):1674-7.

-Lartigau-Roussin C, Paclet MH, Audin H, Toussaint B, Henni T, Raffray L. Macro-ASAT et myélome : une association fortuite? Rev Med Interne 2017 Mar;38(3):210-213.

-Raffray L, Renou F, Bourdier-de-Beauregard M, Lartigau-Roussin C, Mohamed S. Une maladie au traitement hautement compulsif. Rev Med Interne. 2017 Jan;38(1):65-68.  –Printemps de la médecine interne

-Raffray L, Giry C, Vandroux D, Kuli B, Randrianjohany A, Pequin AM, Renou F, Jaffar-Bandjee MC, Gasque P. Major Neutrophilia Observed in Acute Phase of Human Leptospirosis Is Not Associated with Increased Expression of Granulocyte Cell Activation Markers. PLoS One. 2016 Nov 1;11(11):e0165716. doi:10.1371/journal.pone.0165716.

-Raffray L, Giry C, Thirapathi Y, Reboux AH, Jaffar-Bandjee MC, Gasque P. Increased levels of soluble forms of E-selectin and ICAM-1 adhesion molecules during human leptospirosis. PLoS One. 2017;12(7):e0180474. doi.org/10.1371/journal.pone.0180474.

- Audemard-Verger A, Terrier B, Dechartres A, Chanal J, Amoura Z, Le Gouellec N, Cacoub P, Jourde-Chiche N, Urbanski G, Augusto JF, Moulis G, Raffray L at al. Characteristics and Management of IgA Vasculitis (Henoch-Schönlein) in Adults: Data From 260 Patients Included in a French Multicenter Retrospective Survey. Arthritis Rheumatol. 2017 Sep;69(9):1862-1870. doi: 10.1002/art.40178.