English version

Mavingui Patrick

 

 

Research Director (DR1) at CNRS

DYnamicS of Insular Infectious systems (DySIIs) Team 

Contact :
patrick.mavingui[at]cnrs.remove-this.fr

Tél. +262 2 62 21 25 70

GSM. +262 6 92 04 40 20

Scientific expertise

Molecular genetics of host-microbes interactions, mainly dealing with symbioses, genome dynamics, mechanisms of cellular and molecular communication, differential gene expression. Molecular microbial ecology aiming to determine key determinants that control proliferation of infectious agents in hosts. Characterization of effectors and host targets, using biochemical, immunological, genetic and fluorescence spectroscopy techniques. Ecology and health, mosquito-borne diseases (arboviroses) and vector control.

 

Education

  • 2009 HDR, University of Lyon 1, France, Symbiosis and Evolution.

  • 1992 Ph.D., University of Nancy I, France, Microbiology, Microbial Ecology.

  • 1987 Master, Institut National Polytechnique de Lorraine, Nancy, France.

Professional experience

  • Since 2018 : Scientific advisor of SAS Tropical Biocontrol.

  • Since 2016 : Scientific advisor of SAS SymbioTIC (Symbiosis Technology for Insect Control).

  • Since 2015 Research Director at CNRS, University of La Reunion, Reunion Island, France

  • 2010-2015: Research Director at CNRS, University of Lyon I, France

  • 2002-2009: Associate Researcher (CR1) at CNRS, University of Lyon I, France

  • 2001 : Associate Professor, University Geneva, Geneva, Switzerland.

  • 1997-2001 : Permanent Researcher, National Autonomous University of Mexico, Mexico

  • 1994-1996: Associate Researcher, National Autonomous University of Mexico, Mexico

  • 1993: Postdoctoral fellow at Laboratoire de Microbiologie des Sols, INRA, Dijon

 

Referee for Scientific Organizations

  • Head VLIR-UOS–Belgium Own Initiatives

  • ANR, EC2CO, Institut Pasteur

  • Bart Israel

  • CONACyT Mexico

 

Administration of science

  • Director of UMR PIMIT, since January 2015

  • Director of Fédération de Recherche BioST, University of Reunion, since march 2016

  • Director du GDRI “Biodiversité et Développement Durable à Madagascar”, 2011-2014

  • Deputy Director of Fédération de Recherche BioEnvironment, University of Lyon 1, 2011-2015

  • Head of team “ Microbial dynamics and viral transmission”, Lyon 1, 2008-2014.

 

Major Grants

As PI :

  • ANR SEST 2006 “Multipartite interactions virus Chikungunya-Endosymbionts-Moquitoes” 2007-2009.

  • IFB/FRB “Environment and risk of emergence of arboviroses in Madagascar”. 2008.

  • EU FP7 GC-INVAMOFECT “Global change and invasive mosquitoes as infectious disease risks in Europe”. 2013-2017.

  • FEDER VECTOBIOMES “Vectors and microbiomes”. 2017-2020.

  • FEDER REUNION Cohort in population. 2018-2021. CoPI Meilhac O,

 

As Work Package leader:

  • ANR blanc 2006 “Endosymbiosis in Arthropods (Endosymbart)”(2007-2009). Coordinator Didier Bouchon.

  • UE STREP Food Quality & Safety. Micromaize. (2006-2009). Coordinator Yvan Moenne-Loccoz.

  • ACIP Pasteur 2009 « Does the endosymbiont Wolbachia able to affect DENV and CHIKV transmission ? » (2009-2010). Anna-Bella Failloux.

  • ANR blanc « Immunity and Symbiosis in Arthropods » (2011-2014). Coordinator Didier Bouchon.

  • EU H2020 ZIKAlliance “A global alliance for zika virus control and prevention” (2016-2019). Coordinator Xavier de Lamballerie.

 

Publications (period2015-2019)

2019

Cordonin, C., Turpin, M., Bascands, J.-L., Dellagi, K., Mavingui, P., Tortosa, P., & Roche, M. (2019). Three Leptospira Strains From Western Indian Ocean Wildlife Show Highly Distinct Virulence Phenotypes Through Hamster Experimental Infection. Frontiers in Microbiology, 10. doi.org/10.3389/fmicb.2019.00382

Gomard, Y., Lagadec, E., Humeau, L., Pinet, P., Bureau, S., Silva, D. D., … Tortosa, P. (2019). Feral cats do not play a major role in leptospirosis epidemiology on Reunion Island. Epidemiology & Infection, 147. doi.org/10.1017/S0950268819000190

Pascalis, H., Turpin, J., Roche, M., Krejbich, P., Gadea, G., Nten, C. A., … Mavingui, P. (2019). The epidemic of Dengue virus type-2 Cosmopolitan genotype on Reunion Island relates to its active circulation in the Southwestern Indian Ocean neighboring islands. Heliyon, 5(4), e01455. https://doi.org/10.1016/j.heliyon.2019.e01455

Latreille AC, Milesi P, Magalon H, Mavingui P, Atyame CM. 2019. High genetic diversity but no geographical structure of Aedes albopictus populations in Réunion Island. Parasites & Vectors, 12:597. Doi: 10.1186/s13071-019-3840-x.

 

2018

Andrianjafy, T. M., Ravaomanarivo, L. H., Ramanandraibe, V. V., Rakotondramanga, M. F., Mavingui, P., & Lemaire, M. (2018). Synthesis, Bioassays and Field Evaluation of Hydroxycoumarins and their Alkyl Derivatives as Repellents or Kairomones for Aedes albopictus Skuse (Diptera: Culicidae). Journal of Chemical Ecology, 44(3), 299‑311. doi.org/10.1007/s10886-018-0931-7

Clain, E., Sinigaglia, L., Koishi, A. C., Gorgette, O., Gadea, G., Viranaicken, W., … El Kalamouni, C. (2018a). Extract from Aphloia theiformis, an edible indigenous plant from Reunion Island, impairs Zika virus attachment to the host cell surface. Scientific Reports, 8(1), 10856. doi.org/10.1038/s41598-018-29183-2

Cordonin, C., Toty, C., Mavingui, P., & Tortosa, P. (2018). Complete Genome Sequences of Three Leptospira mayottensis Strains from Tenrecs That Are Endemic in the Malagasy Region. Microbiol Res Announc, 7(15), e01188-18. doi.org/10.1128/MRA.01188-18

Destoumieux-Garzón, D., Mavingui, P., Boetsch, G., Boissier, J., Darriet, F., Duboz, P., … Voituron, Y. (2018). The One Health Concept: 10 Years Old and a Long Road Ahead. Frontiers in Veterinary Science, 5. doi.org/10.3389/fvets.2018.00014

Gomard, Y., Cornuault, J., Licciardi, S., Lagadec, E., Belqat, B., Dsouli, N., … Tortosa, P. (2018). Evidence of multiple colonizations as a driver of black fly diversification in an oceanic island. PLOS ONE, 13(8), e0202015. doi.org/10.1371/journal.pone.0202015

Guégan, M., Zouache, K., Démichel, C., Minard, G., Tran Van, V., Potier, P., … Valiente Moro, C. (2018). The mosquito holobiont: fresh insight into mosquito-microbiota interactions. Microbiome, 6(1), 49. doi.org/10.1186/s40168-018-0435-2

Hoarau, F., Le Minter, G., Joffrin, L., Schoeman, M. C., Lagadec, E., Ramasindrazana, B., … Lebarbenchon, C. (2018). Bat Astrovirus in Mozambique. Virology Journal, 15(1), 104. doi.org/10.1186/s12985-018-1011-x

Joffrin, L., Dietrich, M., Mavingui, P., & Lebarbenchon, C. (2018). Bat pathogens hit the road: But which one? PLoS Pathogens, 14(8), e1007134. doi.org/10.1371/journal.ppat.1007134

Lebon, C., Benlali, A., Atyame, C., Mavingui, P., & Tortosa, P. (2018). Construction of a genetic sexing strain for Aedes albopictus: a promising tool for the development of sterilizing insect control strategies targeting the tiger mosquito. Parasites & Vectors, 11(2), 658.

Minard, G., Tran, F.-H., Tran Van, V., Fournier, C., Potier, P., Roiz, D., … Valiente Moro, C. (2018). Shared larval rearing environment, sex, female size and genetic diversity shape Ae. albopictus bacterial microbiota. PloS One, 13(4), e0194521. doi.org/10.1371/journal.pone.0194521

Tetreau, G., Grizard, S., Patil, C. D., Tran, F.-H., Tran Van, V., Stalinski, R., … Valiente Moro, C. (2018). Bacterial microbiota of Aedes aegypti mosquito larvae is altered by intoxication with Bacillus thuringiensis israelensis. Parasites & Vectors, 11(1), 121. doi.org/10.1186/s13071-018-2741-8

2017

Andrianjaly, TM., Ravaomanarivo, LH., Rakotondramanga, M., Ramanandraibe, VV., Mavingui, P.,  Lemaire, M. (2017). New bioassay to evaluate repellency and attractively of chemical products against adults mosquitoes Aedes albopictus and Culex quinquefasciatus. Ann Community Med Pract, 3(1) :1020.

Biscornet, L., Dellagi, K., Pagès, F., Bibi, J., Comarmond, J. de, Mélade, J., Govinden, G., Guernier, V., Lagadec, E., Mélanie, J., Rocamora, G., Le Minter, G., Jaubert, J., Mavingui, P., Tortosa, P. (2017). Human leptospirosis in Seychelles: A prospective study confirms the heavy burden of the disease but suggests that rats are not the main reservoir. PLOS Neglected Tropical Diseases, 11(8), e0005831. doi.org/10.1371/journal.pntd.0005831.

Goubert, C., Henri, H., Minard, G., Valiente Moro, C., Mavingui, P., Vieira, C., & Boulesteix, M. (2017). High-throughput sequencing of transposable element insertions suggests adaptive evolution of the invasive Asian tiger mosquito towards temperate environments. Molecular Ecology, 26(15), 3968‑3981. https://doi.org/10.1111/mec.14184

Lebarbenchon, C., Ramasindrazana, B., Joffrin, L., Bos, S., Lagadec, E., Le Minter, G., Gomard, Y., Tortosa, P., Wilkinson D., & Mavingui, P. (2017). Astroviruses in bats, Madagascar. Emerging Microbes & Infections, 6(6), e58. https://doi.org/10.1038/emi.2017.47

Minard, G., Tran Van, V., Tran, F. H., Melaun, C., Klimpel, S., Koch, L. K., Ly Huynh Kim, K., Tran, NH., Potier, P, Mavingui, P., & Valiente Moro, C. (2017). Identification of sympatric cryptic species of Aedes albopictus subgroup in Vietnam: new perspectives in phylosymbiosis of insect vector. Parasites & Vectors, 10(1), 276. https://doi.org/10.1186/s13071-017-2202-9.

René-Martellet, M., Minard, G., Massot, R., Tran Van, V., Valiente Moro, C., Chabanne, L., & Mavingui, P. (2017). Bacterial microbiota associated with Rhipicephalus sanguineus (s.l.) ticks from France, Senegal and Arizona. Parasites & Vectors, 10(1), 416. https://doi.org/10.1186/s13071-017-2352-9.

Saucereau, Y., Valiente Moro, C., Dieryckx, C., Dupuy, J.-W., Tran, F.-H., Girard, V., Potier, P., & Mavingui, P. (2017). Comprehensive proteome profiling in Aedes albopictus to decipher Wolbachia-arbovirus interference phenomenon. BMC Genomics, 18(1), 635. https://doi.org/10.1186/s12864-017-3985-y.

Tortosa, P., Dellagi, K. M., & Mavingui, P. (2017). Leptospiroses on the French islands of the Indian Ocean. Bulletin Epidémiologique Hebdomadaire - BEH, 8‑9. https://hal.archives-ouvertes.fr/hal-01508690

Zotzmann, S., Steinbrink, A., Schleich, K., Frantzmann, F., Xoumpholphakdy, C., Spaeth, M., Valiente Moro, C., Mavingui, P., & Klimpel, S. (2017). Bacterial diversity of cosmopolitan Culex pipiens and invasive Aedes japonicus from Germany. Parasitology Research, 116(7), 1899-1906. doi.org/10.1007/s00436-017-5466-2

2016

Gadea G et al. 2016. A robust method for the rapid generation of recombinant Zika virus expressing the GFP reporter gene. Virology 497:157-162.

Goubert et al. 2016. High-Throughput Sequencing of Transposable Elements Insertions Provides Evidence for Adaptive Evolution of the Invasive Asian Tiger Mosquito Towards Temperate Environments. bioRxiv. doi: 10.1101/049197.

Moutailler S et al. 2016. Co-infection of Ticks: The Rule Rather Than the Exception. PLOS Neglected Tropical Diseases10 :e0004539

Wilkinson DA et al. 2016. The bacteriome of bat flies (Nycteribiidae) from the Malagasy region: a community shaped by host ecology, bacterial transmission mode, and host-vector specificity. Applied and Environmental Microbiology 82:1778-1788.

 

2015

Goubert C et al. 2016. De novo assembly and annotation of the Asian tiger mosquito (Aedes albopictus) repeatome with dnaPipeTE from raw genomic reads and comparative analysis with the yellow fever mosquito (Aedes aegypti). Genome Biology and Evolution. doi: 10.1093/gbe/evv050.

Minard G et al. 2015. French invasive Asian tiger mosquito populations harbor reduced bacterial microbiota and genetic diversity compared to Vietnamese autochthonous relatives. Front Microbiol 6 :670.

Raquin et al. 2015. Native Wolbachia from Aedes albopictus Blocks Chikungunya Virus Infection In Cellulo. PLoS ONE. 10:e0125066.

René-Martellet M et al. 2015. Update on epidemiology of canine babesiosis in Southern France. BMC Vet Research 11 :223.

 

Books, book chapters and other publications

*Moënne-Loccoz Y, *Mavingui P, Combes C, Normand P, Steinberg C. 2015. Microorganisms and biotic interactions. Chapitre 11, In: Environmental Microbiology: Fundamentals and Applications (J.C. Bertrand, P. Caumette, P. Lebaron, P. Normand, Eds). *Chapter Coordinators.

Mavingui P, Prugnolle F. 2015. Des microbes, des tropiques et des hommes. Chapitre 6, In : Ecologie Tropicale : de l’ombre à la lumière. (P-M Forget, M. Hossaert-McKey, O. Poncy, Eds). Cherche midi.

Mavingui P, Valiente Moro C. 2017. Les arthropodes et leur microbe : unis face à l’adversité. In Ecologie de la Santé : pour une nouvelle lecture de nos maux. (Blanc S, Boëtsch G, Hossaert-McKey M, Renaud F., Eds). Cherche midi. ISBN 978-2-7491-5425-1.

Mavingui P, Moro CV, Tortosa P. 2018. Exploiting symbiotic interactions for vector/disease control. Consulté à l’adresse www.oxfordscholarship.com/view/10.1093/oso/9780198789833.001.0001/oso-9780198789833-chapter-11

 

Invention  – Valorization

  • Patent application N° EP16305863.9 ; appliquant INSERM - CNRS - Université de La Réunion - IRD, 8 July 2016. Genomic sequences encoding for an attenuated mutant Zika virus. Gilles Gadea, Wildriss Viranaicken, Patrick Mavingui, Philippe Desprès.

  • Start-up Symbiosis Technology for Insect Control (SymbioTIC). 2017.

  • Start-up Tropical BioControl (TBC). 2019.

  • Cohort REUNION in population. Funded by FEDER. 2019.