English version

EL KALAMOUNI Chaker

Associate Professor

Coordinator of international relations,

Health faculty, University of Reunion Island.

 

UMR PIMIT

Team Molecular and Cellular mechanisms of infections Agents (MOCA)

 

Contact :

Chaker.el-kalamouni[at]univ-reunion.remove-this.fr

Phone : +262 2 62 93 88 22

Expertise and research areas          

  • Research at the interface between chemistry of natural substances and molecular virology.
  • Chemical and biological characterization of natural substances from medicinal plants.

 

Teaching fields

  • Analytical and general chemistry
  • Physico-chemistry for the biological and pharmaceutical sciences.
  • Therapeutic approaches, antiviral strategies.

 

Education

  • 2010     PhD Phytochemistry, Institut National Polytechnique de Toulouse, France.
  • 2006     Master 2 Supramolecular chemistry, Université de Paul Sabatier, Toulouse, France.
  • 2005     Master 2 Chemical Biology, Université de Paul Sabatier, Toulouse, France.
  • 2004     Master 1 Biochemistry, Lebanese University, Tripoli, Lebanon.

 

Work Experiences

  • 2011 – : Associate Professor, University of Reunion Island, Saint Denis, France
  • 2010 – 2011 : Assistant Professor, University of Rouen, Faculty of Pharmacy, Rouen, France
  • 2009 – 2010 : Assistant Professor, University of Rouen, Faculty of Sciences, Rouen, France

 

Responsibilities

  • 2016 - : Member of the research committee of the University of Reunion Island.
  • 2016 - : Member of the Health Faculty Council.
  • 2016 - : Member of the Academic Council of the university of Reunion Island.
  • 2016 - : Member of PIMIT Laboratory Council.

 

Reviewing activities

Manuscripts in the following fields : natural substances, biological activity of natural substances, virology, antiviral research, phytochemistry, food chemistry.  

 

Research Grant

  • 2015 – 2020 : FEDER Reunion Region (partner)
  • 2017 – 2020 : CAPES COFECUB, collaboration with FIOCRUZ, Molecular Virology Lab
  • 2016 – 2019 : Biodiversity and Health Federation (BioST), Reunion Island University, 4 grants.
  • 2018 : Inserm Transfert

 

National and international collaborations

  • Pr. Jean-Luc Wolfender, School of pharmaceutical sciences, Geneva, Switzerland.
  • Pr. Claudia dos Santos, FIOCRUZ, Molecular Virology Lab, Curitiba, Brazil.
  • Dr Nolwenn Jouvenet, Pasteur Institute, Paris, France.
  • Pr Johan Neyts, Neyt’s Lab, Rega Institute, KU Leuven, Belgium.
  • Dr. Marc Litaudon, Institut de Chimie de Substances Naturelles, CNRS Paris, France.

 

Patent :

Use of Quercetin-3-O-glucoside for the treatment of flavivirus infections, Patent n°18305340.4.

 

Publications :

 

2019

 

1.            Haddad, J. G.; Picard, M.; Benard, S.; Desvignes, C.; Despres, P.; Diotel, N.; El Kalamouni, C. Ayapana triplinervis Essential Oil and Its Main Component Thymohydroquinone Dimethyl Ether Inhibit Zika Virus at Doses Devoid of Toxicity in Zebrafish. Molecules2019, 24,  10.3390/molecules24193447.

2.            Haddad, J. G.; Koishi, A. C.; Gaudry, A.; Nunes Duarte Dos Santos, C.; Viranaicken, W.; Despres, P.; El Kalamouni, C. Doratoxylon apetalum, an Indigenous Medicinal Plant from Mascarene Islands, Is a Potent Inhibitor of Zika and Dengue Virus Infection in Human Cells. Int J Mol Sci2019, 20,  10.3390/ijms20102382.

3.            El Kalamouni, C.; Frumence, E.; Bos, S.; Turpin, J.; Nativel, B.; Harrabi, W.; Wilkinson, D.; Meilhac, O.; Gadea, G.; Desprès, P.; Krejbich-Trotot, P.; Viranaïcken, W. Subversion of the Heme Oxygenase-1 Antiviral Activity by Zika Virus. Viruses2019, 11, 2

4.            Clain, E.; Haddad, J. G.; Koishi, A. C.; Sinigaglia, L.; Rachidi, W.; Despres, P.; Duarte Dos Santos, C. N.; Guiraud, P.; Jouvenet, N.; El Kalamouni, C. The Polyphenol-Rich Extract from Psiloxylon mauritianum, an Endemic Medicinal Plant from Reunion Island, Inhibits the Early Stages of Dengue and Zika Virus Infection. Int J Mol Sci2019, 20,  10.3390/ijms20081860.

 

2018

 

5.            Ralambondrainy, M.; Belarbi, E.; Viranaicken, W.; Baranauskiene, R.; Venskutonis, P. R.; Despres, P.; Roques, P.; El Kalamouni, C.; Selambarom, J. In vitro comparison of three common essential oils mosquito repellents as inhibitors of the Ross River virus. PLoS One2018, 13, e0196757 10.1371/journal.pone.0196757.

6.            Grauzdyte, D.; Pukalskas, A.; Viranaicken, W.; El Kalamouni, C.; Venskutonis, P. R. Protective effects of Phyllanthus phillyreifolius extracts against hydrogen peroxide induced oxidative stress in HEK293 cells. PLoS One2018, 13, e0207672 10.1371/journal.pone.0207672.

7.            Grauzdyte, D.; Pukalskas, A.; El Kalamouni, C.; Venskutonis, P. R. Antioxidant potential and phytochemical composition of extracts obtained from Phyllanthus phillyreifolius by different extraction methods. Nat Prod Res2018, 1-4 10.1080/14786419.2018.1493586.

8.            Gaudry, A.; Bos, S.; Viranaicken, W.; Roche, M.; Krejbich-Trotot, P.; Gadea, G.; Despres, P.; El-Kalamouni, C. The Flavonoid Isoquercitrin Precludes Initiation of Zika Virus Infection in Human Cells. Int J Mol Sci2018, 19,  10.3390/ijms19041093.

9.            Clain, E.; Sinigaglia, L.; Koishi, A. C.; Gorgette, O.; Gadea, G.; Viranaicken, W.; Krejbich-Trotot, P.; Mavingui, P.; Despres, P.; Nunes Duarte Dos Santos, C.; Guiraud, P.; Jouvenet, N.; El Kalamouni, C. Extract from Aphloia theiformis, an edible indigenous plant from Reunion Island, impairs Zika virus attachment to the host cell surface. Sci Rep2018, 8, 10856 10.1038/s41598-018-29183-2.

10.          Clain, E.; Baranauskienė, R.; Kraujalis, P.; Šipailienė, A.; Maždžierienė, R.; Kazernavičiūtė, R.; El Kalamouni, C.; Venskutonis, P. R. Biorefining of Cymbopogon nardus from Reunion Island into essential oil and antioxidant fractions by conventional and high pressure extraction methods. Industrial Crops and Products2018, 126, 158-167 doi.org/10.1016/j.indcrop.2018.10.015.

11.          Bos, S.; Viranaicken, W.; Turpin, J.; El-Kalamouni, C.; Roche, M.; Krejbich-Trotot, P.; Despres, P.; Gadea, G. The structural proteins of epidemic and historical strains of Zika virus differ in their ability to initiate viral infection in human host cells. Virology2018, 516, 265-273 10.1016/j.virol.2017.12.003.

 

2017

 

12.          Viranaicken, W.; Ndebo, A.; Bos, S.; Souque, P.; Gadea, G.; El-Kalamouni, C.; Krejbich-Trotot, P.; Charneau, P.; Despres, P.; Roche, M. Recombinant Zika NS1 Protein Secreted from Vero Cells Is Efficient for Inducing Production of Immune Serum Directed against NS1 Dimer. Int J Mol Sci2017, 19,  10.3390/ijms19010038.

13.          Viranaicken, W.; Nativel, B.; Krejbich-Trotot, P.; Harrabi, W.; Bos, S.; El Kalamouni, C.; Roche, M.; Gadea, G.; Despres, P. ClearColi BL21(DE3)-based expression of Zika virus antigens illustrates a rapid method of antibody production against emerging pathogens. Biochimie2017, 142, 179-182 10.1016/j.biochi.2017.09.011.

14.          El Kalamouni, C.; Venskutonis, P. R.; Zebib, B.; Merah, O.; Raynaud, C.; Talou, T. Antioxidant and Antimicrobial Activities of the Essential Oil of Achillea millefolium L. Grown in France. Medicines (Basel)2017, 4,  10.3390/medicines4020030.

 

2016

 

15.          Krejbich-Trotot, P.; Belarbi, E.; Ralambondrainy, M.; El-Kalamouni, C.; Viranaicken, W.; Roques, P.; Despres, P.; Gadea, G. The growth of arthralgic Ross River virus is restricted in human monocytic cells. Virus Res2016, 225, 64-68 10.1016/j.virusres.2016.09.007.

16.          Gadea, G.; Bos, S.; Krejbich-Trotot, P.; Clain, E.; Viranaicken, W.; El-Kalamouni, C.; Mavingui, P.; Despres, P. A robust method for the rapid generation of recombinant Zika virus expressing the GFP reporter gene. Virology2016, 497, 157-162 10.1016/j.virol.2016.07.015.

17.          Frumence, E.; Roche, M.; Krejbich-Trotot, P.; El-Kalamouni, C.; Nativel, B.; Rondeau, P.; Misse, D.; Gadea, G.; Viranaicken, W.; Despres, P. The South Pacific epidemic strain of Zika virus replicates efficiently in human epithelial A549 cells leading to IFN-beta production and apoptosis induction. Virology2016, 493, 217-226 10.1016/j.virol.2016.03.006.