ROCHE Marjolaine

RESEARCH AREAS

(1) Human health and tropical infectious diseases

(2) Physiopathology of arbovirus in particular flavivirus (Zika and Dengue) and their viral proteins specifically the NS1 in cellular and rodent models

(3) Infectious disease in case of metabolic disorder

(4) Modulation of cellular metabolism during viral infection

EDUCATION

• 2005 PhD, Avignon University, France, Science and Agronomy

• 2000 Master 2, Aix-Marseille University, Luminy, France, Biotechnologies

WORK EXPERIENCES

• 2015- Researcher/Lecturer, University of the Reunion, PIMIT, Saint Denis, France
• 2011-2015 Researcher/Lecturer, University of the Reunion, GRI, Saint Denis, France
• 2008-2014 Postdoctoral Fellow, Pharmacology Department, University of Medicine and Dentistry of New Jersey, Newark, USA
• 2005-2007, Assistant Researcher/Lecturer, University of the Reunion, LBGM, Saint Denis, France

RESPONSIBILITIES

• Mission Leader in Research/Development/Innovation for the Univeristy, since 2017
• Member of Student and Formation Committee of the University, 2010-2013

REVIEWING ACTIVITIES

• Manuscripts in human virology and dietary compounds.

RESEARCH GRANT

• FEDER Région Réunion 2015-2020 (partner)
• Biodiversity and Health Federation (BioST), la Réunion University, 2016
• NIH 2007-2009 (partner)

PUBLICATIONS (ORCID ID: orcid.org)

2019

A chimeric zika virus between viral strains MR766 and BeH819015 highlights a role for E-glycan loop in antibody-mediated virus neutralization. Frumence E, Viranaicken W., Bos S., Alvarez-Martinez M.-T., Roche M., Arnaud D.J. Gadea G., Desprès P. Vaccines. 2019 Jun 24;7(2). pii: E55. doi: 10.3390/vaccines7020055.

The epidemic of Dengue virus type-2 Cosmopolitan genotype on Reunion Island relates to its active circulation in the Southwestern Indian Ocean neighboring islands. Pascalis H, Turpin J, Roche M, Krejbich P, Gadea G, Nten CA, Desprès P, Mavingui P. Heliyon. 2019, Apr 10;5(4):e01455. doi: 10.1016/j.heliyon.2019.e01455

Three leptospira strains from Western Indian Ocean wildlife show highly distinct virulence phenotypes through hamster experimental infection. Cordonin C, Turpin M., Bascands J.-L., Dellagi K., Mavingui P., Tortosa P., Roche M. Frontiers in micr. 2019, 10, 382. doi: 10.3389/fmicb.2019.00382

2018

The Flavonoid Isoquercitrin Precludes Initiation of Zika Virus Infection in Human Cells. Gaudry A, Bos S, Viranaicken W, Roche M, Krejbich-Trotot P, Gadea G, Desprès P, El-Kalamouni C. Int J Mol Sci. 2018 Apr 5;19(4). doi: 10.3390/ijms19041093. (IF 3,5)

The structural proteins of epidemic and historical strains of Zika virus differ in their ability to initiate viral infection in human host cells. Bos S, Viranaicken W, Turpin J, El-Kalamouni C, Roche M, Krejbich-Trotot P, Desprès P, Gadea G. Virology 2018 516:265–273

2017

ClearColi BL21(DE3)-based expression of Zika virus antigens illustrates a rapid method of antibody production against emerging pathogens. Viranaicken W, Nativel B, Krejbich-Trotot P, Harrabi W, Bos S, El Kalamouni C, Roche M, Gadea G, Desprès P. Biochimie. 2017 Nov;142:179-182.

Recombinant Zika NS1 Protein Secreted from Vero Cells Is Efficient for Inducing Production of Immune Serum Directed against NS1 Dimer. Viranaicken W, Ndebo A, Bos S, Souque P, Gadea G, El-Kalamouni C, Krejbich-Trotot P, Charneau P, Desprès P, Roche M. Int J Mol Sci. 2017 Dec23;19(1).

2016

Cadmium reduces the efficiently of Sindbis virus replication in human cells and promotes their survival by inhibiting apoptosis. Frumence E., Guiraud P., Roche M.Biochem. Biophy. Reports 2016 Aug;8:151-156

The South Pacific epidemic strain of Zika virus replicates efficiently in humans epithelial A549 cells leading to IFN-b production and apoptosis induction. Frumence E., Roche. M, Krejbich-Trotot P., El-Kalamouni C., Nativel B., Rondeau P., Missé D., Gadéa G., Viranaicken W., Desprès P. 2016 Jun;493:217-26