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KREJBICH-TROTOT Pascale

PhD in Cell Biology, Microbiology

HDR (research conducting skills)

 

Maître de conferences des Universités (MCU), Lecturer, University of Reunion Island. National Council of Universities Section CNU 65 (cellular biology).

Qualification for the position of University Professors sections CNU 65 and 64

Teaching manager of the Master1 level in Health Biology

Referent of Equal Opportunities for Men and Women division, Health faculty, University of Reunion Island.

 

Research activity at UMR PIMIT

Team Molecular and Cellular mechanisms of infections Agents (MOCA)

 

Expertise and research areas         

  • Cellular and molecular Biology
  • Pathogen-Human host cell interactions.
  • Arboviruses (Chikungunya virus, Zika virus, Dengue virus) and pathogenesis.
  • Cell responses to infection, cell death by apoptosis, autophagy, cell stresses, innate immunity

 

Teaching fields

  • Cellular Biology, Molecular Biology, Physiology
  • molecular and cellular bases of pathologies
  • teaching levels: first year in health studies, health education institutes, Scientific bachelor and master

 

Education

  • 1993    PhD University Paris Sorbonne (UPMC) « Transcription activity in Embryonic Carcinoma cells: Systematic study by mutagenesis of the regulatory region of the Polyoma virus ». Virus and Differentiation Laboratory, UPR272 CNRS, Cancer Research Institute, Villejuif.
  • 2013    Habilitation à Diriger les Recherches (UR) « Roles of Apoptosis and Autophagy in the physiopathology of Chikungunya: On the way to the cellular mechanisms involved in the emergence of chronic post-infection arthralgia. »

 

Work Experiences

  • 2015-          MCU University of La Réunion, UFR Santé. Research at the PIMIT Unit.
  • 2011-2015 MCU University of La Réunion. Research at the Research Group in Infectious Immunopathology (EA4517)
  • 2007-2011 MCU, at the disposal of La Réunion University from Versailles St Quentin en Yvelines University (UVSQ). Research at the Research Group in Infectious Immunopathology (EA4517), CHU Felix Guyon, St Denis La Réunion, dir Pr P. Gasque.
  • 2003-2007 childcare leave
  • 1995-2003 Lecturer, University UVSQ, UFR Sciences. Research at the Laboratory of Cellular Biologie and Genetics (Génétique et Biologie cellulaire), équipe apoptose, CNRS FRE 2445 ex UPRES-A 8087, Versailles, dir Pr B. Mignotte.
  • 1993-1995 Post doctoral fellow as Assistant Professor, University Sorbonne Université Paris (Pierre et Marie Curie) UFR Sciences. Research at the Regulation of Gene Expression Unit of Pasteur’s Institute (Unité de Régulation de l'Expression génétique). Institut Pasteur, Paris, dir Pr A. Danchin.
  • 1990-1993Docteur-Moniteur d’Initiation à l’Enseignement Supérieur, (instructor for initiation to higher education UPMC). Laboratoire Virus et Différenciation, UPR272 CNRS, IRSC/Hopital Paul Brousse, Villejuif, dir Pr D. Blangy

 

Responsibilities

  • 2016-2020 Elected Member of the Academic Council of the university of Reunion Island. Health Faculty Council.
  • 2016 - 2020 Elected Member of the Research Committee of the University of Reunion Island.
  • 2016 - 2020 Elected Member of PIMIT Laboratory Council.

 

Reviewing activities

Manuscripts in diverse fields of biology: cell biology and virology.  

 

Research Grant

  • 2015 - 2020 : FEDER Reunion Region (partner)
  • 2015 - 2019 : Biodiversity and Health Federation (BioST), Reunion Island University.

 

 

Publications (ORCID 0000-0001-7329-171:

 

-2019

w Turpin J, Frumence E, Desprès P, Viranaïcken W* and Krejbich-Trotot P*

The ZIKA Virus Delays Cell Death Through the Anti-Apoptotic Bcl-2 Family Proteins

Cells, 2019 oct 29;8(11).  PMID: 31671831 DOI: 10.3390/cells8111338 (Impact Factor 5.7).

 

w Turpin J, Frumence E, Harrabi W, El Kalamouni C, Desprès P, Krejbich-Trotot P* , Viranaïcken W* Crosstalk Between Endoplasmic Reticulum Stress and The Unfolded Protein Response During ZIKA Virus Infection September 2019

DOI: 10.20944/preprints201910.0024.v1

 

w Pascalis H,Turpin J, Roche M, Krejbich-Trotot P, Gadea G, Nten CA, Desprès P, Mavingui P.

The epidemic of Dengue virus type-2 Cosmopolitan genotype on Reunion Island relates to its active circulation in the Southwestern Indian Ocean neighboring islands.

Heliyon, 2019 Apr 10;5(4):e01455. doi: 10.1016/j.heliyon.2019.e01455. PMID: 31008393 (Impact Factor 0.84 ; citations : 1).

 

-2018

w El Kalamouni C, Frumence E, Bos S, Turpin J, Nativel B, Harrabi W, Wilkinson D, Meilhac O, Gadea G, Desprès P, Krejbich-Trotot P*, Viranaïcken W*

Subversion of the Heme Oxygenase-1 antiviral activity by Zika virus.

Viruses, (Impact Factor 3.8 ; citations : 4).

 

w Clain E, Sinigaglia L, Koishi A C, Gorgette O, Gadea G, Viranaicken W, Krejbich-Trotot P, Mavingui P, Desprès P, Duarte Dos Santos C N, Guiraud P, Jouvenet N, El Kalamouni C*.

Extract from Aphloia theiformis, an edible indigenous plant from Reunion Island, impairs Zika virus attachment to the host cell surface.

Scientific Reports 2018 Jul 18;8(1):10856. PMID: 30022045 (Impact Factor 4.2 ; citations : 5).

                    

w Gaudry A, Bos S, Viranaicken W, Roche M, Krejbich-Trotot P, Gadea G, Desprès P, El-Kalamouni C.

The Flavonoid Isoquercitrin Precludes Initiation of Zika Virus Infection in Human Cells.

Int J Mol Sci. 2018 Apr 5;19(4). PMID: 29621184 (4.2 Impact Factor; citations : 7).

 

w Bos S, Viranaicken W, Turpin J, El-Kalamouni C, Krejbich-Trotot P, Desprès P*, Gadea G*.

The structural proteins of epidemic and historical strains of Zika virus differ in the ability to initiate viral infection in human host cells.

Virology2018 03 1;516:265-273. PMID: 29395111 (Impact Factor 3.3, citations: 16).

 

2017

w Viranaicken W, Ndebo A, Bos S, Souque P, Gadea G, El-Kalamouni C, Krejbich-Trotot P, Charneau P, Desprès P*, Roche M*.

Recombinant Zika NS1 Protein Secreted from Vero Cells Is Efficient for Inducing Production of Immune Serum Directed against NS1 Dimer.

Int J Mol Sci 2017 Dec 23;19(1). PMID: 29295477 (Impact Factor 4.2 citations: 2).

 

w Viranaicken W, Nativel B, Harrabi W, Krejbich-Trotot P, Bos S, El Kalamouni C, Roche M, Desprès P* (2017).

ClearColi BL21(DE3)-based expression of Zika virus antigens illustrates a rapid method of antibody production against emerging pathogens.

Biochimie 142:179-82 PMID: 29295477 (Impact Factor 3.3 citations: 3).

 

2016

w Gadea G, Bos S, Krejbich-Trotot P, Clain E, Viranaicken W, El-Kalamouni C, Mavingui P, Desprès P*.

A robust method for the rapid generation of recombinant Zika virus expressing the GFP reporter gene.

Virology 2016 497:157-62. PMID: 27471954 (Impact Factor 3.3, citations 28).

 

w Frumence E, Roche M, Krejbich-Trotot P, El-Kalamouni C, Nativel B, Rondeau P, Missé D, Gadea G, Viranaicken W*, Desprès P*. The South Pacific epidemic strain of Zika virus replicates efficiently in human epithelial A549 cells leading to IFN-β production and apoptosis induction.

Virology 2016 493:217-26. PMID: 27060565 (Impact Factor 3.3, citations 52).

 

w Krejbich-Trotot P, Belarbi E, Ralambondrainy M, El-Kalamouni C, Viranaicken W, Roques P, Desprès P, Gadea G*. The growth of arthralgic Ross River virus is restricted in human monocytic cells.

Virus Research2016 ; Oct 2;225:64-68. PMID: 27637347 (Impact Factor 2,7 citations 2)