Gadea Gilles

RESEARCH INTERESTS

I am currently investigating host-pathogen interactions 1. from the pathogen point-of-view, by studying molecular determinants of their infectivity and 2. from the host point-of-view, by investigating the consequences of viral infections on cellular physiology. My studies are focused on arboviruses, with Dengue and Zika viruses as actual models of investigation.

RESEARCH AREAS

(1) Biology for health
(2) Host-pathogen interactions relative to tropical vector-borne diseases
(3) Molecular tools to study emerging infectious agents
(4) Translational research

EDUCATION

• 2016 HDR, la Réunion University, Saint Denis, France, Biology for Health
• 2004 PhD, Montpellier University, France, Biology for Health
• 2000 Master 2, Aix-Marseille University, Luminy, France, Immunotechnologies

WORK EXPERIENCES

• 2015- Researcher Inserm, PIMIT, Saint Denis, France

• 2008-2014 Researcher Inserm, CRBM, Montpellier, France

• 2005-2008 Postdoctoral Fellow, ICR, London, United-Kingdom

RESPONSIBILITIES

• Member of Inserm Specialized Scientific Committee 2, 2012-2013

• Member of CRBM Institute committee, 2010-2013

• Member of PIMIT Institute committee, 2015-2019

• Deputy Director, 2020-2025

REVIEWING ACTIVITIES

• Manuscripts in diverse fields of biology: cell biology, cancer biology, metastasis, arbovirology.

• Local grant programs (Rhône-Alpes, Limousin, Haute-Garonne)

RESEARCH GRANT

• SIRIC Montpellier Cancer, 2013.

• FEDER Région Réunion 2015-2020 (partner)

• Biodiversity and Health Federation (BioST), la Réunion University, 2018

NATIONAL AND INTERNATIONAL COLLABORATIONS

• Pr. Claudia dos Santos, Fiocruz, Molecular Virology Lab, Curitiba, Brazil

• Pr. Marie-Lise Gougeon, Pasteur Institute, Innate immunity and virus Lab, Paris, France

• Dr Robert Mamoun, Ciloa, Montpellier, France

• Pr Richard Y Zhao, Molecular diagnostics Lab, University of Maryland, Baltimore, USA

PATENTS

• Genomic sequences encoding for an attenuated mutant Zika virus (WO/2018/007575).

• Vaccine compositions comprising an attenuated mutant Zika virus (WO/2017/220748).

• Delta133p53beta and Delta133p53gamma isoforms are biomarkers of cancer stem cells (WO/2016/120495).

• Reprogramming method for producing induced pluripotent stem cells (iPSC) (WO/2016/120493).

PUBLICATIONS (ORCID ID: orcid.org/0000-0001-6325-4866)

2019

Sandra Bos, Wildriss Viranaicken, Etienne Frumence, Ge Li, Philippe Desprès, Richard Y. Zhao* and Gilles Gadea*

The Envelope Residues E152/156/158 of Zika Virus Influence the Early Stages of Virus Infection in Human Cells

Cells. 2019, 8(11) 1444. doi.org/10.3390/cells8111444

Frumence E, Viranaicken W, Bos S, Alvarez-Martinez MT, Roche M, Arnaud JD, Gadea G, Desprès P.

A Chimeric Zika Virus between Viral Strains MR766 and BeH819015 Highlights a Role for E-glycan Loop in Antibody-mediated Virus Neutralization.

Vaccines. 2019 Jun 24;7(2). pii: E55. doi: 10.3390/vaccines7020055.

Frumence E, Viranaicken W, Gadea G, Desprès P.

A GFP Reporter MR766-Based Flow Cytometry Neutralization Test for Rapid Detection of Zika Virus-Neutralizing Antibodies in Serum Specimens.

Vaccines. 2019 Jul 16;7(3). pii: E66. doi: 10.3390/vaccines7030066.

Pascalis H, Turpin J, Roche M, Krejbich P, Gadea G, Nten CA, Desprès P, Mavingui P.

The epidemic of Dengue virus type-2 Cosmopolitan genotype on Reunion Island relates to its active circulation in the Southwestern Indian Ocean neighboring islands.

Heliyon. 2019 Apr 10;5(4):e01455.

Vanwalscappel B, Gadea G, Desprès P.

A Viperin Mutant Bearing the K358R Substitution Lost its Anti-ZIKA Virus Activity.

Int J Mol Sci. 2019 Mar 29;20(7). pii: E1574.

Li G, Bos S, Tsetsarkin KA, Pletnev AG, Desprès P, Gadea G*, Zhao RY*.

The Roles of prM-E Proteins in Historical and Epidemic Zika Virus-mediated Infection and Neurocytotoxicity.

Viruses. 2019 Feb 14;11(2). pii: E157.

2018

El Kalamouni C, Frumence E, Bos S, Turpin J, Nativel B, Harrabi W, Wilkinson DA, Meilhac O, Gadea G, Desprès P, Krejbich-Trotot P, Viranaïcken W.

Subversion of the Heme Oxygenase-1 Antiviral Activity by Zika Virus.

Viruses. 2018 Dec 20;11(1). pii: E2.

Bos S, Gadea G, Despres P.

Dengue: a growing threat requiring vaccine development for disease prevention.

Pathog Glob Health. 2018 Sep;112(6):294-305.

Clain E, Sinigaglia L, Koishi AC, Gorgette O, Gadea G, Viranaicken W, Krejbich-Trotot P, Mavingui P, Desprès P, Nunes Duarte Dos Santos C, Guiraud P, Jouvenet N, El Kalamouni C.

Extract from Aphloia theiformis, an edible indigenous plant from Reunion Island, impairs Zika virus attachment to the host cell surface.

Sci Rep. 2018 Jul 18;8(1):10856.

Lee I, Bos S, Li G, Wang S, Gadea G, Desprès P, Zhao RY.

Probing Molecular Insights into Zika Virus–Host Interactions.

Viruses. 2018 May 2;10(5).

Gaudry A, Bos S, Viranaicken W, Roche M, Krejbich-Trotot P, Gadea G, Desprès P, El-Kalamouni C.

The Flavonoid Isoquercitrin Precludes Initiation of Zika Virus Infection in Human Cells.

Int J Mol Sci. 2018 Apr 5;19(4).

Bos S, Viranaicken W, Turpin J, El-Kalamouni C, Roche M, Krejbich-Trotot P, Desprès P, Gadea G.

The structural proteins of epidemic and historical strains of Zika virus differ in the ability to initiate viral infection in human cells.

Virology. 2018 Mar 516:265-273.

2017

Wildriss Viranaicken, Alexia Ndebo, Sandra Bos, Philippe Souque, Gilles Gadea, Chaker el-Kalamouni, Pascale Krejbich-Trotot, Pierre Charneau, Philippe Desprès, Marjolaine Roche

Recombinant Zika NS1 protein secreted from Vero cells is efficient for inducing production of immune serum directed against NS1 dimer 


Int J Mol Sci. 2017 Dec 23;19(1)

Viranaicken W, Nativel B, Krejbich-Trotot P, Harrabi W, Bos S, El Kalamouni C, Roche M, Gadea G, Desprès P.

ClearColi BL21(DE3)-based expression of Zika virus antigens illustrates a rapid method of antibody production against emerging pathogens.

Biochimie. 2017 Nov;142:179-182.

Nikola Arsic, Alexandre Ho-Pun-Cheung, Crapez Evelyne, Eric Assenat, Marta Jarlier, Christelle Anguille, Manon Colard, Mikaël Pezet, Pierre Roux and Gilles Gadea

The p53 isoform delta133p53ß regulates cancer cell apoptosis in a RhoB-dependent manner.

PLoS ONE 2017 Apr 6;12(4):e0175607

2016

Pascale Krejbich-Trotot, Essia Belarbi, Miora Ralambondrainy, Chaker El-Kalamouni, Wildriss Viranaicken, Pierre Roques, Philippe Desprès, Gilles Gadea.

The growth of arthralgic Ross River virus is restricted in monocytic cells.

Virus Research 2016 Sep 13;225:64-68.

G Gadea, N Arsic, K Fernandes, A Diot, SM.Joruiz, S Abdallah, V Meuray, S Vinot, C Anguille, J Remenyi, MP Khoury, P Quinlan, CA Purdie, LB Jordan, FV Fuller-Pace, M de Toledo, M Cren, AM Thompson, JC Bourdon and P Roux.

TP53 drives invasion through expression of its delta133p53ß variant.

eLife 2016 Sep 15;5. pii: e14734.

Gadea G, Bos S, Krejbich-Trotot P, Clain E, Viranaicken W, El-Kalamouni C, Mavingui P, Desprès P.

A robust method for the rapid generation of recombinant Zika virus expressing the GFP reporter gene.

Virology 2016 Jul 26;497:157-162.